Alcohol, no. That experiment didnt' work.

Tobacco will be very rarely used in the U.S. in 100 yrs. The percentage of smokers has dropped by 50% in the last 40 yrs or so.

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A human being should be able to change a diaper, plan an invasion, butcher a hog, conn a ship, design a building, write a sonnet, balance accounts, build a wall, set a bone, comfort the dying, take orders, give orders, cooperate, act alone, solve equations, analyze a new problem, pitch manure, program a computer, cook a tasty meal, fight efficiently, die gallantly. Specialization is for insects.
— Robert Heinlein, Time Enough for Love